The concept of dynamical diseases has been in existence for well over 20 years, with numerous reviews drawing attention to disorders that are characterized by the recurrence of certain symptoms, or exhibit oscillations that appear in the intensity of an ongoing nervous system disease. Neuropsychiatric and neurological diseases exhibiting periodicity or cyclicity include Bipolar Disorder, Schizophrenia, Seasonal Affective Disorder, Klein-Levin Syndrome, Sleep Disorders, Binging, Epilepsy, Multiple Sclerosis, Jet-Lag and Headache. The time course of the disorders can range from seconds and minutes to months and years. This symposium will examine a number of dynamical disorders of the nervous system, with the aim of providing an overarching perspective into potential underlying mechanisms, detection, prevention and treatment strategy.